DAGL enzyme

E874322

The DAGL enzyme is a key biosynthetic enzyme in the endocannabinoid system that produces the signaling lipid 2-arachidonoylglycerol (2-AG) from diacylglycerol.

All labels observed (1)

Label Occurrences
DAGL enzyme canonical 1

How this entity was disambiguated

Statements (47)

Predicate Object
instanceOf diacylglycerol lipase ⓘ
enzyme ⓘ
associatedWith endocannabinoid signaling ⓘ
energy homeostasis ⓘ
inflammation regulation ⓘ
neurodevelopment ⓘ
pain modulation ⓘ
retrograde signaling at synapses ⓘ
synaptic plasticity ⓘ
catalyzes conversion of diacylglycerol to 2-arachidonoylglycerol ⓘ
encodedBy DAGLA gene ⓘ
DAGLB gene ⓘ
foundIn brain ⓘ
central nervous system ⓘ
hasActivity diacylglycerol lipase activity ⓘ
hasCofactor requires access to membrane phospholipid-derived diacylglycerol ⓘ
hasFunction biosynthesis of 2-arachidonoylglycerol ⓘ
hydrolysis of diacylglycerol ⓘ
hasIsoform DAGLα ⓘ
DAGLβ ⓘ
hasPathway 2-AG biosynthetic pathway ⓘ
influences neurotransmitter release ⓘ
synaptic transmission ⓘ
inhibitedBy selective DAGL inhibitors ⓘ
tetrahydrolipstatin (orlistat, weakly) ⓘ
involvesProcess endocannabinoid biosynthesis ⓘ
lipid signaling ⓘ
retrograde endocannabinoid signaling at excitatory synapses ⓘ
retrograde endocannabinoid signaling at inhibitory synapses ⓘ
localization neuronal dendrites ⓘ
plasma membrane ⓘ
locatedAt postsynaptic neuron membranes ⓘ
memberOf serine hydrolase family ⓘ
opposes monoacylglycerol lipase-mediated 2-AG degradation ⓘ
partOf endocannabinoid system ⓘ
produces 2-arachidonoylglycerol ⓘ
product 2-arachidonoylglycerol ⓘ
free fatty acid ⓘ
regulates endocannabinoid tone ⓘ
levels of 2-arachidonoylglycerol ⓘ
relatedTo monoacylglycerol lipase ⓘ
requires serine hydrolase catalytic machinery ⓘ
substrate diacylglycerol ⓘ
taxon Homo sapiens ⓘ
Mus musculus ⓘ
upstreamOf CB1 receptor activation ⓘ
CB2 receptor activation ⓘ

How these facts were elicited

Referenced by (1)

Full triples — surface form annotated when it differs from this entity's canonical label.

endocannabinoid system → hasPart → DAGL enzyme ⓘ