hematopoietic stem cells
E802042
Hematopoietic stem cells are multipotent stem cells in the bone marrow that give rise to all blood and immune cell lineages throughout life.
All labels observed (1)
| Label | Occurrences |
|---|---|
| hematopoietic stem cells canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T9477921 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: hematopoietic stem cells Context triple: [CD4+ T cells, originateFrom, hematopoietic stem cells]
-
A.
Cambridge Blood and Stem Cell Biobank
The Cambridge Blood and Stem Cell Biobank is a major research facility that collects, processes, and stores human blood and stem cell samples to support biomedical and translational research.
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B.
Yamanaka factors
Yamanaka factors are a set of transcription factors that can reprogram adult somatic cells into induced pluripotent stem cells, revolutionizing regenerative medicine and stem cell research.
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C.
Center for Cellular and Molecular Therapeutics
The Center for Cellular and Molecular Therapeutics is a research institute specializing in developing gene and cell-based therapies for pediatric and genetic diseases.
-
D.
Cell Therapy
"Cell Therapy" is a socially conscious Southern hip hop track by Goodie Mob, known for its commentary on surveillance, systemic oppression, and life in Atlanta’s inner city.
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E.
B lymphocytes
B lymphocytes are a type of white blood cell central to the adaptive immune system, responsible for producing antibodies and mediating humoral immunity.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: hematopoietic stem cells Target entity description: Hematopoietic stem cells are multipotent stem cells in the bone marrow that give rise to all blood and immune cell lineages throughout life.
-
A.
Cambridge Blood and Stem Cell Biobank
The Cambridge Blood and Stem Cell Biobank is a major research facility that collects, processes, and stores human blood and stem cell samples to support biomedical and translational research.
-
B.
Yamanaka factors
Yamanaka factors are a set of transcription factors that can reprogram adult somatic cells into induced pluripotent stem cells, revolutionizing regenerative medicine and stem cell research.
-
C.
Center for Cellular and Molecular Therapeutics
The Center for Cellular and Molecular Therapeutics is a research institute specializing in developing gene and cell-based therapies for pediatric and genetic diseases.
-
D.
Cell Therapy
"Cell Therapy" is a socially conscious Southern hip hop track by Goodie Mob, known for its commentary on surveillance, systemic oppression, and life in Atlanta’s inner city.
-
E.
B lymphocytes
B lymphocytes are a type of white blood cell central to the adaptive immune system, responsible for producing antibodies and mediating humoral immunity.
- F. None of above. chosen
Statements (65)
| Predicate | Object |
|---|---|
| instanceOf |
adult stem cell
ⓘ
multipotent stem cell ⓘ somatic stem cell ⓘ stem cell ⓘ |
| canBeDamagedBy |
chemotherapy
ⓘ
ionizing radiation ⓘ |
| differentiationControlledBy |
transcription factor GATA-2
ⓘ
transcription factor RUNX1 ⓘ transcription factor SCL/TAL1 ⓘ |
| expresses |
CD117 (c-Kit)
ⓘ
linked to:
c-KIT
CD34 (human, subset) ⓘ CD90 (Thy-1) ⓘ Sca-1 (mouse) ⓘ |
| firstAppearIn | aorta-gonad-mesonephros region ⓘ |
| foundIn |
birds
ⓘ
fish ⓘ mammals ⓘ reptiles ⓘ |
| givesRiseTo |
B lymphocytes
ⓘ
T lymphocytes ⓘ dendritic cells ⓘ erythrocytes ⓘ granulocytes ⓘ lymphoid progenitor cells ⓘ megakaryocytes ⓘ monocytes ⓘ myeloid progenitor cells ⓘ natural killer cells ⓘ platelets ⓘ |
| hasProperty |
clonogenic potential
ⓘ
long-term repopulating ability ⓘ multipotency ⓘ quiescence ⓘ self-renewal capacity ⓘ |
| interactsWith |
endothelial cells
ⓘ
mesenchymal stromal cells ⓘ osteoblasts ⓘ |
| lacksExpressionOf | lineage markers (Lin−) ⓘ |
| locatedIn |
bone marrow
ⓘ
fetal liver ⓘ peripheral blood ⓘ spleen ⓘ thymus (early development) ⓘ
linked to:
Thymus
umbilical cord blood ⓘ |
| mobilizedBy |
G-CSF
ⓘ
plerixafor ⓘ |
| originatesDuring | embryonic hematopoiesis ⓘ |
| playsRoleIn |
immune system maintenance
ⓘ
lifelong blood cell production ⓘ |
| regulatedBy |
CXCL12 (SDF-1)
ⓘ
TGF-beta ⓘ interleukin-3 ⓘ interleukin-6 ⓘ stem cell factor ⓘ thrombopoietin ⓘ |
| resideIn | bone marrow niche ⓘ |
| studiedUsing |
bone marrow transplantation assays
ⓘ
colony-forming unit assays ⓘ |
| usedFor |
bone marrow transplantation
ⓘ
hematopoietic stem cell transplantation ⓘ treatment of aplastic anemia ⓘ treatment of hemoglobinopathies ⓘ treatment of inherited immunodeficiencies ⓘ treatment of leukemia ⓘ treatment of lymphoma ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: hematopoietic stem cells Description of subject: Hematopoietic stem cells are multipotent stem cells in the bone marrow that give rise to all blood and immune cell lineages throughout life.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.