NTRK1
E1549339
UNEXPLORED
NTRK1 is a proto-oncogene encoding the TRKA receptor tyrosine kinase, which mediates nerve growth factor signaling and can drive cancer when involved in gene fusions.
All labels observed (2)
| Label | Occurrences |
|---|---|
| NTRK1 canonical | 2 |
| tropomyosin receptor kinase A | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T22690631 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: NTRK1 Context triple: [Vitrakvi, targetsGeneFusion, NTRK1]
-
A.
TRK
TRK is the FAA location identifier for Truckee Tahoe Airport, a public airport serving the Truckee and Lake Tahoe region in California.
-
B.
GRIN1
GRIN1 is a gene that encodes an essential subunit of NMDA-type glutamate receptors, which play a key role in synaptic transmission and plasticity in the central nervous system.
-
C.
Ephrin-B3
Ephrin-B3 is a transmembrane ligand of the Eph family of receptor tyrosine kinases that plays key roles in nervous system development and also serves as an entry receptor for certain henipaviruses.
-
D.
ERBB3
ERBB3 is a member of the ErbB family of receptor tyrosine kinases that plays a key role in cell signaling, particularly in cancer, often through potent mitogenic and survival pathways.
-
E.
ERBB4
ERBB4 is a receptor tyrosine kinase of the ErbB/EGFR family involved in cell signaling pathways that regulate cell growth, differentiation, and development.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: NTRK1 Target entity description: NTRK1 is a proto-oncogene encoding the TRKA receptor tyrosine kinase, which mediates nerve growth factor signaling and can drive cancer when involved in gene fusions.
-
A.
TRK
TRK is the FAA location identifier for Truckee Tahoe Airport, a public airport serving the Truckee and Lake Tahoe region in California.
-
B.
GRIN1
GRIN1 is a gene that encodes an essential subunit of NMDA-type glutamate receptors, which play a key role in synaptic transmission and plasticity in the central nervous system.
-
C.
Ephrin-B3
Ephrin-B3 is a transmembrane ligand of the Eph family of receptor tyrosine kinases that plays key roles in nervous system development and also serves as an entry receptor for certain henipaviruses.
-
D.
ERBB3
ERBB3 is a member of the ErbB family of receptor tyrosine kinases that plays a key role in cell signaling, particularly in cancer, often through potent mitogenic and survival pathways.
-
E.
ERBB4
ERBB4 is a receptor tyrosine kinase of the ErbB/EGFR family involved in cell signaling pathways that regulate cell growth, differentiation, and development.
- F. None of above. chosen
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.