Synthesis of crown ethers
E1478963
UNEXPLORED
"Synthesis of crown ethers" is the landmark work in which chemist Charles J. Pedersen first reported the creation of crown ether compounds, foundational molecules in host–guest and supramolecular chemistry.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Synthesis of crown ethers canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T21337723 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Synthesis of crown ethers Context triple: [Charles J. Pedersen, notableWork, Synthesis of crown ethers]
-
A.
Corey–Nicolaou macrolactonization
Corey–Nicolaou macrolactonization is a widely used organic synthesis reaction that forms large-ring lactones from hydroxy acids via an activated ester intermediate.
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B.
Mitsunobu macrolactonization
Mitsunobu macrolactonization is a variant of the Mitsunobu reaction used in organic synthesis to form large-ring lactones by intramolecular esterification under mild, dehydrative conditions.
-
C.
The Logic of Chemical Synthesis
The Logic of Chemical Synthesis is a seminal book by chemist Elias J. Corey that systematically presents the principles and strategies of retrosynthetic analysis for designing complex organic molecule syntheses.
-
D.
Yamaguchi macrolactonization
Yamaguchi macrolactonization is a widely used organic synthesis method for forming large-ring lactones via intramolecular esterification activated by a mixed anhydride, particularly valuable in complex natural product synthesis.
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E.
Enantioselective Chemical Synthesis
Enantioselective Chemical Synthesis is a foundational work in organic chemistry that systematically presents strategies and methods for constructing chiral molecules with high stereocontrol.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Synthesis of crown ethers Target entity description: "Synthesis of crown ethers" is the landmark work in which chemist Charles J. Pedersen first reported the creation of crown ether compounds, foundational molecules in host–guest and supramolecular chemistry.
-
A.
Corey–Nicolaou macrolactonization
Corey–Nicolaou macrolactonization is a widely used organic synthesis reaction that forms large-ring lactones from hydroxy acids via an activated ester intermediate.
-
B.
Mitsunobu macrolactonization
Mitsunobu macrolactonization is a variant of the Mitsunobu reaction used in organic synthesis to form large-ring lactones by intramolecular esterification under mild, dehydrative conditions.
-
C.
The Logic of Chemical Synthesis
The Logic of Chemical Synthesis is a seminal book by chemist Elias J. Corey that systematically presents the principles and strategies of retrosynthetic analysis for designing complex organic molecule syntheses.
-
D.
Yamaguchi macrolactonization
Yamaguchi macrolactonization is a widely used organic synthesis method for forming large-ring lactones via intramolecular esterification activated by a mixed anhydride, particularly valuable in complex natural product synthesis.
-
E.
Enantioselective Chemical Synthesis
Enantioselective Chemical Synthesis is a foundational work in organic chemistry that systematically presents strategies and methods for constructing chiral molecules with high stereocontrol.
- F. None of above. chosen
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.