S1P4 receptor
E1466875
UNEXPLORED
The S1P4 receptor is a G protein–coupled sphingosine-1-phosphate receptor primarily expressed in immune cells, where it regulates immune cell trafficking and function.
All labels observed (1)
| Label | Occurrences |
|---|---|
| S1P4 receptor canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T21057570 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: S1P4 receptor Context triple: [fingolimod, targetsReceptor, S1P4 receptor]
-
A.
S1P3 receptor
The S1P3 receptor is a G protein–coupled sphingosine-1-phosphate receptor involved in regulating vascular tone, immune cell trafficking, and cardiovascular function.
-
B.
PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
-
C.
CB2 receptor
The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
-
D.
CCR5
CCR5 is a human cell-surface chemokine receptor best known as a key co-receptor for HIV entry into immune cells and as a target for both natural resistance and gene-editing interventions against HIV infection.
-
E.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: S1P4 receptor Target entity description: The S1P4 receptor is a G protein–coupled sphingosine-1-phosphate receptor primarily expressed in immune cells, where it regulates immune cell trafficking and function.
-
A.
S1P3 receptor
The S1P3 receptor is a G protein–coupled sphingosine-1-phosphate receptor involved in regulating vascular tone, immune cell trafficking, and cardiovascular function.
-
B.
PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
-
C.
CB2 receptor
The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
-
D.
CCR5
CCR5 is a human cell-surface chemokine receptor best known as a key co-receptor for HIV entry into immune cells and as a target for both natural resistance and gene-editing interventions against HIV infection.
-
E.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
- F. None of above. chosen
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.