LDL receptor
E1405305
UNEXPLORED
The LDL receptor is a cell-surface protein that binds and internalizes low-density lipoprotein particles, playing a central role in cholesterol homeostasis and cardiovascular disease risk.
All labels observed (1)
| Label | Occurrences |
|---|---|
| LDL receptor canonical | 2 |
How this entity was disambiguated
This entity first appeared as the object of triple T19992636 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: LDL receptor Context triple: [APOE gene, proteinProductInteractsWith, LDL receptor]
-
A.
NPC1L1 transporter
The NPC1L1 transporter is an intestinal membrane protein that mediates cholesterol absorption from the gut and is inhibited by the lipid-lowering drug ezetimibe.
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B.
Frizzled receptor
Frizzled receptors are a family of G protein–coupled receptor-like proteins that serve as primary cell-surface receptors for Wnt signaling, regulating key processes in development and cell fate determination.
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C.
Ldl
Ldl is the official station code for Leiden Lammenschans railway station in the Netherlands.
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D.
Friedewald
Friedewald is a small German locality historically associated with the nobility of Thuringia and Hesse.
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E.
PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: LDL receptor Target entity description: The LDL receptor is a cell-surface protein that binds and internalizes low-density lipoprotein particles, playing a central role in cholesterol homeostasis and cardiovascular disease risk.
-
A.
NPC1L1 transporter
The NPC1L1 transporter is an intestinal membrane protein that mediates cholesterol absorption from the gut and is inhibited by the lipid-lowering drug ezetimibe.
-
B.
Frizzled receptor
Frizzled receptors are a family of G protein–coupled receptor-like proteins that serve as primary cell-surface receptors for Wnt signaling, regulating key processes in development and cell fate determination.
-
C.
Ldl
Ldl is the official station code for Leiden Lammenschans railway station in the Netherlands.
-
D.
Friedewald
Friedewald is a small German locality historically associated with the nobility of Thuringia and Hesse.
-
E.
PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
- F. None of above. chosen
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.