NPC1L1 transporter
E1361794
UNEXPLORED
The NPC1L1 transporter is an intestinal membrane protein that mediates cholesterol absorption from the gut and is inhibited by the lipid-lowering drug ezetimibe.
All labels observed (1)
| Label | Occurrences |
|---|---|
| NPC1L1 transporter canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T19157391 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: NPC1L1 transporter Context triple: [Zetia, targets, NPC1L1 transporter]
-
A.
ABCG2 gene
The ABCG2 gene encodes a membrane transporter protein involved in multidrug resistance and the efflux of various xenobiotics and endogenous compounds across cellular membranes.
-
B.
APOE gene
The APOE gene encodes apolipoprotein E, a key protein in lipid metabolism whose variants, especially ε4, strongly influence risk for Alzheimer’s disease and cardiovascular disorders.
-
C.
CYP3A5
CYP3A5 is a liver-expressed cytochrome P450 enzyme that metabolizes various drugs and xenobiotics, contributing to interindividual variability in drug clearance.
-
D.
BCRP
BCRP is the Central Reserve Bank of Peru, the country’s monetary authority responsible for maintaining monetary stability and managing its currency and international reserves.
-
E.
BCRP
BCRP (Breast Cancer Resistance Protein) is an ATP-binding cassette (ABC) efflux transporter involved in multidrug resistance and the transport of various drugs and xenobiotics across cellular membranes.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: NPC1L1 transporter Target entity description: The NPC1L1 transporter is an intestinal membrane protein that mediates cholesterol absorption from the gut and is inhibited by the lipid-lowering drug ezetimibe.
-
A.
ABCG2 gene
The ABCG2 gene encodes a membrane transporter protein involved in multidrug resistance and the efflux of various xenobiotics and endogenous compounds across cellular membranes.
-
B.
APOE gene
The APOE gene encodes apolipoprotein E, a key protein in lipid metabolism whose variants, especially ε4, strongly influence risk for Alzheimer’s disease and cardiovascular disorders.
-
C.
CYP3A5
CYP3A5 is a liver-expressed cytochrome P450 enzyme that metabolizes various drugs and xenobiotics, contributing to interindividual variability in drug clearance.
-
D.
BCRP
BCRP is the Central Reserve Bank of Peru, the country’s monetary authority responsible for maintaining monetary stability and managing its currency and international reserves.
-
E.
BCRP
BCRP (Breast Cancer Resistance Protein) is an ATP-binding cassette (ABC) efflux transporter involved in multidrug resistance and the transport of various drugs and xenobiotics across cellular membranes.
- F. None of above. chosen
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.