Mitsunobu macrolactonization
E1358594
UNEXPLORED
Mitsunobu macrolactonization is a variant of the Mitsunobu reaction used in organic synthesis to form large-ring lactones by intramolecular esterification under mild, dehydrative conditions.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Mitsunobu macrolactonization canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T19066446 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Mitsunobu macrolactonization Context triple: [Corey–Nicolaou macrolactonization, relatedTo, Mitsunobu macrolactonization]
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A.
Corey–Nicolaou macrolactonization
Corey–Nicolaou macrolactonization is a widely used organic synthesis reaction that forms large-ring lactones from hydroxy acids via an activated ester intermediate.
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B.
Yamaguchi macrolactonization
Yamaguchi macrolactonization is a widely used organic synthesis method for forming large-ring lactones via intramolecular esterification activated by a mixed anhydride, particularly valuable in complex natural product synthesis.
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C.
Eschenmoser sulfide contraction
Eschenmoser sulfide contraction is an organic rearrangement reaction that converts certain sulfur-containing intermediates into carbonyl compounds, widely used in complex molecule and natural product synthesis.
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D.
Tsuji–Trost reactions
Tsuji–Trost reactions are palladium-catalyzed allylic substitution processes widely used in organic synthesis to form carbon–carbon and carbon–heteroatom bonds with high regio- and stereocontrol.
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E.
Stork enamine reaction
The Stork enamine reaction is a key carbon–carbon bond-forming method in organic chemistry that uses enamines as nucleophiles to alkylate or acylate carbonyl compounds in a controlled, selective way.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Mitsunobu macrolactonization Target entity description: Mitsunobu macrolactonization is a variant of the Mitsunobu reaction used in organic synthesis to form large-ring lactones by intramolecular esterification under mild, dehydrative conditions.
-
A.
Corey–Nicolaou macrolactonization
Corey–Nicolaou macrolactonization is a widely used organic synthesis reaction that forms large-ring lactones from hydroxy acids via an activated ester intermediate.
-
B.
Yamaguchi macrolactonization
Yamaguchi macrolactonization is a widely used organic synthesis method for forming large-ring lactones via intramolecular esterification activated by a mixed anhydride, particularly valuable in complex natural product synthesis.
-
C.
Eschenmoser sulfide contraction
Eschenmoser sulfide contraction is an organic rearrangement reaction that converts certain sulfur-containing intermediates into carbonyl compounds, widely used in complex molecule and natural product synthesis.
-
D.
Tsuji–Trost reactions
Tsuji–Trost reactions are palladium-catalyzed allylic substitution processes widely used in organic synthesis to form carbon–carbon and carbon–heteroatom bonds with high regio- and stereocontrol.
-
E.
Stork enamine reaction
The Stork enamine reaction is a key carbon–carbon bond-forming method in organic chemistry that uses enamines as nucleophiles to alkylate or acylate carbonyl compounds in a controlled, selective way.
- F. None of above. chosen
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.