Notch intracellular domain
E1342625
UNEXPLORED
The Notch intracellular domain is the cleaved, cytoplasmic fragment of the Notch receptor that translocates to the nucleus to regulate gene transcription in the Notch signaling pathway.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Notch intracellular domain canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T18784286 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Notch intracellular domain Context triple: [Notch, produces, Notch intracellular domain]
-
A.
Sox2
Sox2 is a key transcription factor that maintains stem cell pluripotency and self-renewal and is widely used in cellular reprogramming.
-
B.
PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
-
C.
c-Myc
c-Myc is a proto-oncogene transcription factor that regulates cell growth, proliferation, and metabolism and is frequently dysregulated in cancer.
-
D.
Ephrin-B3
Ephrin-B3 is a transmembrane ligand of the Eph family of receptor tyrosine kinases that plays key roles in nervous system development and also serves as an entry receptor for certain henipaviruses.
-
E.
Ephrin-B2
Ephrin-B2 is a cell surface ligand involved in developmental signaling that also serves as a critical entry receptor for several pathogenic viruses, including Hendra virus.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Notch intracellular domain Target entity description: The Notch intracellular domain is the cleaved, cytoplasmic fragment of the Notch receptor that translocates to the nucleus to regulate gene transcription in the Notch signaling pathway.
-
A.
Sox2
Sox2 is a key transcription factor that maintains stem cell pluripotency and self-renewal and is widely used in cellular reprogramming.
-
B.
PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
-
C.
c-Myc
c-Myc is a proto-oncogene transcription factor that regulates cell growth, proliferation, and metabolism and is frequently dysregulated in cancer.
-
D.
Ephrin-B3
Ephrin-B3 is a transmembrane ligand of the Eph family of receptor tyrosine kinases that plays key roles in nervous system development and also serves as an entry receptor for certain henipaviruses.
-
E.
Ephrin-B2
Ephrin-B2 is a cell surface ligand involved in developmental signaling that also serves as a critical entry receptor for several pathogenic viruses, including Hendra virus.
- F. None of above. chosen
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.