histamine H2 receptor

Target entity: histamine H2 receptor
Context triple: [cimetidine, actsOn, histamine H2 receptor]

• A. H2 receptor antagonist cimetidine
  H2 receptor antagonist cimetidine is a pioneering anti-ulcer medication that reduces stomach acid production by blocking histamine H2 receptors in the gastric parietal cells.
• B. M2 muscarinic acetylcholine receptor
  The M2 muscarinic acetylcholine receptor is a G protein–coupled receptor subtype primarily found in the heart, where it mediates parasympathetic (vagal) effects such as slowing heart rate and reducing contractility.
• C. somatostatin receptor
  A somatostatin receptor is a G protein–coupled membrane receptor that binds the peptide hormone somatostatin to inhibit hormone secretion and modulate neurotransmission and cell proliferation.
• D. CB2 receptor
  The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
• E. H-2
  H-2 is an Interstate Highway in Hawaii that connects Honolulu with the central part of Oʻahu, including the city of Wahiawā and the vicinity of Schofield Barracks.
• F. None of above. chosen
• G. Unsure - the case is ambiguous/there is not enough information to decide.

Target entity: histamine H2 receptor
Target entity description: The histamine H2 receptor is a G protein–coupled receptor primarily found in the stomach that mediates gastric acid secretion and is targeted by H2-blocker drugs used to treat ulcers and reflux.

• A. H2 receptor antagonist cimetidine
  H2 receptor antagonist cimetidine is a pioneering anti-ulcer medication that reduces stomach acid production by blocking histamine H2 receptors in the gastric parietal cells.
• B. M2 muscarinic acetylcholine receptor
  The M2 muscarinic acetylcholine receptor is a G protein–coupled receptor subtype primarily found in the heart, where it mediates parasympathetic (vagal) effects such as slowing heart rate and reducing contractility.
• C. somatostatin receptor
  A somatostatin receptor is a G protein–coupled membrane receptor that binds the peptide hormone somatostatin to inhibit hormone secretion and modulate neurotransmission and cell proliferation.
• D. CB2 receptor
  The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
• E. H-2
  H-2 is an Interstate Highway in Hawaii that connects Honolulu with the central part of Oʻahu, including the city of Wahiawā and the vicinity of Schofield Barracks.
• F. None of above. chosen