aminolevulinate synthase 1
E1294464
UNEXPLORED
Aminolevulinate synthase 1 is a mitochondrial enzyme that catalyzes the first and rate-limiting step of heme biosynthesis in non-erythroid cells.
All labels observed (1)
| Label | Occurrences |
|---|---|
| aminolevulinate synthase 1 canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T17871512 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: aminolevulinate synthase 1 Context triple: [Givlaari, hasMolecularTarget, aminolevulinate synthase 1]
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A.
indoleamine 2,3-dioxygenase 1
Indoleamine 2,3-dioxygenase 1 is an immune-regulatory enzyme that catalyzes the initial oxidative degradation of tryptophan along the kynurenine pathway, influencing inflammation, tolerance, and tumor immune evasion.
-
B.
UGT1A1
UGT1A1 is a liver enzyme that glucuronidates bilirubin and various drugs, playing a key role in their detoxification and elimination from the body.
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C.
indoleamine 2,3-dioxygenase 2
Indoleamine 2,3-dioxygenase 2 is an immune-regulatory heme-containing enzyme that catalyzes the oxidative degradation of tryptophan along the kynurenine pathway, influencing inflammation and immune tolerance.
-
D.
CYP1A2
CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.
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E.
Luzein
Luzein is a Swiss municipality in the canton of Graubünden, known for its alpine landscape and traditional rural character.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: aminolevulinate synthase 1 Target entity description: Aminolevulinate synthase 1 is a mitochondrial enzyme that catalyzes the first and rate-limiting step of heme biosynthesis in non-erythroid cells.
-
A.
indoleamine 2,3-dioxygenase 1
Indoleamine 2,3-dioxygenase 1 is an immune-regulatory enzyme that catalyzes the initial oxidative degradation of tryptophan along the kynurenine pathway, influencing inflammation, tolerance, and tumor immune evasion.
-
B.
UGT1A1
UGT1A1 is a liver enzyme that glucuronidates bilirubin and various drugs, playing a key role in their detoxification and elimination from the body.
-
C.
indoleamine 2,3-dioxygenase 2
Indoleamine 2,3-dioxygenase 2 is an immune-regulatory heme-containing enzyme that catalyzes the oxidative degradation of tryptophan along the kynurenine pathway, influencing inflammation and immune tolerance.
-
D.
CYP1A2
CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.
-
E.
Luzein
Luzein is a Swiss municipality in the canton of Graubünden, known for its alpine landscape and traditional rural character.
- F. None of above. chosen
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.