PARP enzymes
E1159678
UNEXPLORED
PARP enzymes are a family of nuclear proteins that detect DNA damage and catalyze poly(ADP-ribosyl)ation of target proteins to regulate DNA repair, genomic stability, and cell death.
All labels observed (2)
| Label | Occurrences |
|---|---|
| PARP enzymes canonical | 1 |
| PARP1 | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T15478586 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: PARP enzymes Context triple: [NAD+, isSubstrateOf, PARP enzymes]
-
A.
DNA ligase
DNA ligase is an essential enzyme that joins breaks in the sugar-phosphate backbone of DNA, enabling processes such as DNA replication and genetic recombination.
-
B.
TARDBP
TARDBP is a gene encoding the TDP-43 protein, a DNA/RNA-binding protein whose abnormal aggregation is a key pathological feature in amyotrophic lateral sclerosis and related neurodegenerative diseases.
-
C.
SMCR8-WDR41 complex
The SMCR8-WDR41 complex is a protein assembly that partners with C9orf72 to regulate autophagy and lysosomal function, particularly in the context of neurodegenerative disease mechanisms.
-
D.
CDK6
CDK6 is a cyclin-dependent kinase that regulates cell cycle progression and is a key target in certain cancer therapies.
-
E.
RNA polymerase II
RNA polymerase II is the eukaryotic enzyme complex responsible for transcribing DNA into messenger RNA and many non-coding RNAs, playing a central role in gene expression.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: PARP enzymes Target entity description: PARP enzymes are a family of nuclear proteins that detect DNA damage and catalyze poly(ADP-ribosyl)ation of target proteins to regulate DNA repair, genomic stability, and cell death.
-
A.
DNA ligase
DNA ligase is an essential enzyme that joins breaks in the sugar-phosphate backbone of DNA, enabling processes such as DNA replication and genetic recombination.
-
B.
TARDBP
TARDBP is a gene encoding the TDP-43 protein, a DNA/RNA-binding protein whose abnormal aggregation is a key pathological feature in amyotrophic lateral sclerosis and related neurodegenerative diseases.
-
C.
SMCR8-WDR41 complex
The SMCR8-WDR41 complex is a protein assembly that partners with C9orf72 to regulate autophagy and lysosomal function, particularly in the context of neurodegenerative disease mechanisms.
-
D.
CDK6
CDK6 is a cyclin-dependent kinase that regulates cell cycle progression and is a key target in certain cancer therapies.
-
E.
RNA polymerase II
RNA polymerase II is the eukaryotic enzyme complex responsible for transcribing DNA into messenger RNA and many non-coding RNAs, playing a central role in gene expression.
- F. None of above. chosen
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.