Corey– Ziegler– Ziegler– Roush reaction
GPTKB entity
Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:chemical_compound
|
| gptkbp:bfsLayer |
5
|
| gptkbp:bfsParent |
gptkb:Elias_James_Corey
|
| gptkbp:application |
material science
pharmaceutical chemistry polymer chemistry |
| gptkbp:defense_mechanism |
formation of lithium enolate
nucleophilic attack on carbonyl protonation of enolate rearrangement of intermediates |
| gptkbp:developed_by |
gptkb:E._J._Corey
gptkb:D._Roush gptkb:R._Ziegler |
| gptkbp:field |
organometallic chemistry
reaction mechanism studies synthetic organic chemistry |
| gptkbp:first_described_by |
gptkb:1980s
|
| gptkbp:historical_significance |
influence on modern organic chemistry
advancement in synthetic methods |
| https://www.w3.org/2000/01/rdf-schema#label |
Corey– Ziegler– Ziegler– Roush reaction
|
| gptkbp:involves |
carbonyl compounds
lithium reagents |
| gptkbp:is_essential_for |
organic synthesis
|
| gptkbp:is_used_for |
synthesis of alcohols
synthesis of ketones |
| gptkbp:notable_for |
selectivity
C-C bond formation high yields C-N bond formation C-O bond formation C-S bond formation C-X bond formation |
| gptkbp:notable_recipients |
lithium salts
unwanted side products |
| gptkbp:products |
alcohols
ketones |
| gptkbp:related_to |
Grignard reaction
Wittig reaction |
| gptkbp:requires |
dry conditions
|
| gptkbp:research_areas |
catalysis
reaction kinetics asymmetric synthesis reaction optimization mechanistic studies |
| gptkbp:safety_features |
reactive intermediates
toxic reagents |
| gptkbp:type |
organometallic reaction
|
| gptkbp:was_a_catalyst_for |
gptkb:lithium_diisopropylamide
|
| gptkbp:was_a_response_to |
nucleophilic attack
nucleophilic addition low temperature inert atmosphere |