Corey– Yamamoto reaction
GPTKB entity
Statements (46)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:chemical_compound
|
| gptkbp:application |
pharmaceutical synthesis
material science organic synthesis |
| gptkbp:average_temperature |
room temperature
reflux conditions |
| gptkbp:developed_by |
gptkb:1980s
|
| gptkbp:dissolved |
gptkb:in-game_currency
THF |
| gptkbp:dividend_yield |
high yields
|
| gptkbp:has_limitations |
sensitive to moisture
not suitable for all aryl halides requires specific substrates |
| gptkbp:historical_significance |
advancement in organic chemistry
contribution to cross-coupling methods influence on synthetic strategies |
| https://www.w3.org/2000/01/rdf-schema#label |
Corey– Yamamoto reaction
|
| gptkbp:improves |
optimization of reaction conditions
use of alternative catalysts use of ligands |
| gptkbp:involves |
halogenated compounds
organolithium reagents |
| gptkbp:mechanism_of_action |
radical pathway
|
| gptkbp:named_after |
gptkb:E._J._Corey
gptkb:K._Yamamoto |
| gptkbp:notable_contributor |
alkyl halides
metal salts |
| gptkbp:related_to |
gptkb:Negishi_reaction
Suzuki reaction Stille reaction |
| gptkbp:response_time |
several hours
|
| gptkbp:safety |
toxic byproducts
flammable reagents |
| gptkbp:selection_process |
high selectivity
|
| gptkbp:type |
cross-coupling reaction
|
| gptkbp:used_for |
synthesis of aryl ethers
|
| gptkbp:was_a_catalyst_for |
copper salts
|
| gptkbp:was_a_response_to |
nucleophilic substitution
anhydrous conditions oxidative addition reductive elimination transmetalation coupling of radicals formation of aryl radicals |
| gptkbp:bfsParent |
gptkb:Elias_James_Corey
|
| gptkbp:bfsLayer |
5
|