Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:chemical_compound
|
| gptkbp:application |
drug discovery
material science bioconjugation |
| gptkbp:characterized_by |
formation of five-membered ring
formation of nitrogen-containing heterocycles |
| gptkbp:developed_by |
gptkb:Elias_James_Corey
gptkb:Rudolf_Huisgen |
| gptkbp:dividend_yield |
1,2,3-triazoles
|
| gptkbp:first_described_by |
1960s
|
| https://www.w3.org/2000/01/rdf-schema#label |
Corey– Huisgen reaction
|
| gptkbp:involves |
nucleophilic attack
alkynes azides electrophilic center |
| gptkbp:is_essential_for |
click chemistry
|
| gptkbp:is_used_in |
biomedical research
polymer chemistry |
| gptkbp:mechanism_of_action |
[3+2] cycloaddition
|
| gptkbp:named_after |
gptkb:Elias_James_Corey
gptkb:Rudolf_Huisgen |
| gptkbp:performed_in |
in aqueous conditions
in organic solvents |
| gptkbp:produces |
triazoles
|
| gptkbp:related_to |
Huisgen reaction
click chemistry principles |
| gptkbp:requires |
alkyne source
azide source |
| gptkbp:stereochemistry |
highly selective
regioselective |
| gptkbp:technique |
labeling biomolecules
synthesizing complex molecules functionalization of surfaces |
| gptkbp:type |
1,3-dipolar cycloaddition
|
| gptkbp:type_of |
cycloaddition reaction
|
| gptkbp:used_in |
synthesis of heterocycles
|
| gptkbp:was_a_response_to |
thermal conditions
has been optimized for various substrates can be performed under mild conditions can be scaled up is widely studied click chemistry is versatile copper catalysis has applications in drug delivery has applications in imaging techniques has applications in vaccine development is highly efficient utilizes azide-alkyne coupling utilizes copper(I) catalysis |
| gptkbp:bfsParent |
gptkb:Elias_James_Corey
|
| gptkbp:bfsLayer |
5
|