Corey– Hoffmann reaction
GPTKB entity
Statements (48)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:chemical_compound
|
| gptkbp:bfsLayer |
5
|
| gptkbp:bfsParent |
gptkb:Elias_James_Corey
gptkb:E._J._Corey |
| gptkbp:applies_to |
aldehydes
ketones |
| gptkbp:first_described_by |
gptkb:1972
|
| gptkbp:form |
C-C bonds
|
| https://www.w3.org/2000/01/rdf-schema#label |
Corey– Hoffmann reaction
|
| gptkbp:involves |
nucleophilic attack
alkylation electrophilic addition deprotonation |
| gptkbp:is_used_by |
complex molecules
|
| gptkbp:named_after |
gptkb:E._J._Corey
gptkb:R._Hoffmann |
| gptkbp:produced_by |
α,β-unsaturated carbonyl compounds
|
| gptkbp:related_to |
aldol reaction
Michael addition |
| gptkbp:requires |
strong base
|
| gptkbp:significance |
synthetic organic chemistry
|
| gptkbp:technique |
carbon chain elongation
|
| gptkbp:type |
organic synthesis
|
| gptkbp:type_of |
carbonyl chemistry
|
| gptkbp:used_in |
synthesis of natural products
|
| gptkbp:utilizes |
gptkb:lithium_diisopropylamide
|
| gptkbp:was_a_response_to |
has been reviewed in literature
can be performed under mild conditions can be regioselective can be scaled up for industrial use can be used in total synthesis can be monitored by NMR can be optimized for yield can be performed in one pot can be stereoselective can lead to multiple products has been studied extensively can be applied to various substrates can be catalyzed by metals enolates forms new stereocenters has applications in agrochemicals has applications in materials science has applications in pharmaceuticals has been cited in patents has been used in academic research has been used in teaching organic chemistry involves conjugate addition |