Corey– Friedel– Crafts reaction
GPTKB entity
Statements (57)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:chemical_compound
|
| gptkbp:applies_to |
aromatic compounds
|
| gptkbp:can_be_used_to |
synthesize complex organic molecules
|
| gptkbp:can_be_used_to_modify |
natural products
synthetic compounds |
| gptkbp:can_create |
polycyclic aromatic hydrocarbons
|
| gptkbp:can_lead_to |
side reactions
isomers byproducts |
| gptkbp:developed_by |
gptkb:Elias_James_Corey
|
| gptkbp:first_described_by |
1950s
|
| https://www.w3.org/2000/01/rdf-schema#label |
Corey– Friedel– Crafts reaction
|
| gptkbp:involves |
electrophilic substitution
|
| gptkbp:is_applied_in |
heterocyclic compounds
functionalized aromatic compounds |
| gptkbp:is_considered |
a key reaction in organic chemistry
a versatile reaction |
| gptkbp:is_described_as |
chemical literature
|
| gptkbp:is_essential_for |
organic synthesis
|
| gptkbp:is_influenced_by |
reaction time
concentration of reactants catalyst choice electrophile strength substrate structure |
| gptkbp:is_monitored_by |
HPLC
NMR spectroscopy GC-MS |
| gptkbp:is_optimized_for |
temperature control
pressure control |
| gptkbp:is_part_of |
synthetic methodology
|
| gptkbp:is_related_to |
gptkb:Friedel–_Crafts_acylation
|
| gptkbp:is_studied_in |
catalysis
reaction kinetics mechanistic chemistry |
| gptkbp:is_taught_in |
organic chemistry courses
|
| gptkbp:is_used_in |
materials science
industrial applications pharmaceutical chemistry polymer chemistry fine chemical synthesis |
| gptkbp:named_after |
Corey and Friedel-Crafts
|
| gptkbp:performed_in |
polar solvents
solvent-free conditions non-polar solvents |
| gptkbp:produces |
alkylated aromatic compounds
arylated aromatic compounds |
| gptkbp:related_to |
Friedel– Crafts reaction
|
| gptkbp:requires |
gptkb:Catalyst
|
| gptkbp:sensitivity |
reaction conditions
|
| gptkbp:suitable_for |
non-aromatic compounds
|
| gptkbp:type |
alkylation reaction
arylation reaction |
| gptkbp:uses |
Lewis acids
|
| gptkbp:was_a_catalyst_for |
aluminum chloride
boron trifluoride |
| gptkbp:bfsParent |
gptkb:E._J._Corey
|
| gptkbp:bfsLayer |
6
|