Corey–Mitsunobu reaction
GPTKB entity
Statements (46)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
chemical reaction
|
| gptkbp:application |
synthesis of amines
synthesis of esters synthesis of ethers synthesis of thioethers |
| gptkbp:developedBy |
gptkb:E._J._Corey
T. Mitsunobu |
| gptkbp:field |
materials science
pharmaceutical chemistry medicinal chemistry polymer chemistry |
| gptkbp:gameMechanics |
formation of an intermediate
involves inversion of configuration |
| gptkbp:hasDepartment |
requires excess reagents
sensitive to sterics side reactions possible |
| gptkbp:historicalSignificance |
important in synthetic organic chemistry
contributed to the development of new methodologies recognized_in_Nobel_Prize-winning_work |
| https://www.w3.org/2000/01/rdf-schema#label |
Corey–Mitsunobu reaction
|
| gptkbp:interactsWith |
depends on substrate
high yields possible optimization required |
| gptkbp:internationalClassification |
temperature control
anhydrous conditions non-aqueous solvents |
| gptkbp:involves |
azodicarboxylates
phosphine_reagents |
| gptkbp:isPortrayedBy |
1981
|
| gptkbp:namedAfter |
gptkb:E._J._Corey
T. Mitsunobu |
| gptkbp:produces |
alkylated products
|
| gptkbp:relatedTo |
organic synthesis
functional group transformations alkylation reactions Mitsunobu_reaction |
| gptkbp:requires |
base
|
| gptkbp:safetyFeatures |
proper ventilation required
flammable solvents toxic_reagents |
| gptkbp:supplyChain |
carboxylic acid
phosphine oxide |
| gptkbp:type |
nucleophilic substitution
|
| gptkbp:usedFor |
conversion of alcohols to other functional groups
|
| gptkbp:was_a_catalyst_for |
triphenylphosphine
diethyl azodicarboxylate |