Statements (83)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:alias |
BRCA1-associated RING domain 1
|
| gptkbp:associated_with |
gptkb:Oncology
ovarian cancer |
| gptkbp:code |
gptkb:BARD1_protein
|
| gptkbp:discovered_by |
gptkb:1996
|
| gptkbp:genetic_studies |
increased cancer risk
|
| gptkbp:has_function |
tumor suppressor
|
| gptkbp:has_role |
apoptosis
|
| gptkbp:has_variants |
single nucleotide polymorphisms (SNPs)
|
| https://www.w3.org/2000/01/rdf-schema#label |
BARD1 gene
|
| gptkbp:interacts_with |
gptkb:BRCA1_protein
|
| gptkbp:involved_in |
DNA repair
homologous recombination |
| gptkbp:is_associated_with |
cancer risk assessment
genetic predisposition to cancer tumor microenvironment interactions tumor aggressiveness poor prognosis in cancer patients response to DNA damage inherited cancer syndromes tumor recurrence |
| gptkbp:is_expressed_in |
various tissues
adipose tissue brain tissue breast tissue lung tissue prostate tissue ovarian tissue skin tissue placental tissue testicular tissue lymphatic tissue |
| gptkbp:is_involved_in |
cell cycle regulation
cellular homeostasis cellular stress response cellular proliferation tumorigenesis cellular differentiation genomic stability cancer progression cellular signaling pathways protein-protein interactions cellular repair mechanisms cellular repair pathways cellular signaling networks tumor immune evasion cellular apoptosis pathways cellular stress response pathways cancer cell apoptosis cancer cell migration cancer cell survival cellular repair response tumorigenic processes tumor suppression mechanisms cancer stem cell dynamics |
| gptkbp:is_linked_to |
gptkb:hereditary_breast_and_ovarian_cancer_syndrome
tumor heterogeneity tumor microenvironment cancer metastasis radiation sensitivity cancer treatment resistance chemotherapy response chemosensitivity |
| gptkbp:is_part_of |
DNA damage response pathway
BRCA1 signaling pathway |
| gptkbp:is_regulated_by |
estrogen
|
| gptkbp:is_studied_for |
genetic testing
personalized medicine therapeutic interventions therapeutic targets clinical implications biomarker potential cancer biomarkers |
| gptkbp:is_studied_in |
cancer research
|
| gptkbp:is_targeted_at |
gptkb:gene_therapy
|
| gptkbp:located_in |
human chromosome 2
|
| gptkbp:mapped_to |
NCBI Gene ID 585
|
| gptkbp:orthologs |
other species
|
| gptkbp:part_of |
BARD1-BRCA1 complex
|
| gptkbp:regulates |
cell cycle
|
| gptkbp:bfsParent |
gptkb:BARD1_protein
|
| gptkbp:bfsLayer |
8
|