Statements (48)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:healthcare_organization
|
| gptkbp:activities |
modulates gene expression
inhibits keratinocyte proliferation reduces sebum production |
| gptkbp:brand |
Accutane
Roaccutane |
| gptkbp:café |
5288820
|
| gptkbp:class |
gptkb:product
|
| gptkbp:composed_of |
can be synthesized from retinal
can be synthesized from retinol |
| gptkbp:contraindication |
pregnancy
breastfeeding |
| gptkbp:developed_by |
vitamin A
|
| gptkbp:discovered_by |
gptkb:1980s
|
| gptkbp:dissolved |
insoluble in water
soluble in organic solvents |
| gptkbp:enemy |
CHEMB L1200970
|
| gptkbp:excretion |
urine
feces |
| gptkbp:healthcare |
gptkb:battle
|
| https://www.w3.org/2000/01/rdf-schema#label |
13-cis retinoic acid
|
| gptkbp:ingredients |
C20 H28 O2
|
| gptkbp:is_atype_of |
D10 B A01
|
| gptkbp:is_available_on |
oral capsule
oral solution |
| gptkbp:is_monitored_by |
liver function tests
lipid levels |
| gptkbp:is_used_for |
treatment of certain types of cancer
treatment of acne |
| gptkbp:mass |
300.44 g/mol
|
| gptkbp:pharmacokinetics |
metabolized in the liver
absorbed in the gastrointestinal tract |
| gptkbp:previous_name |
(2 E,4 E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
|
| gptkbp:products |
gptkb:all-trans_retinoic_acid
gptkb:tretinoin retinol retinyl palmitate |
| gptkbp:side_effect |
dry skin
headaches muscle aches nosebleeds chapped lips |
| gptkbp:social_structure |
contains a carboxylic acid group
contains a cyclohexene ring contains conjugated double bonds |
| gptkbp:type_of |
19882-08-3
|
| gptkbp:bfsParent |
gptkb:RAR_(Retinoic_Acid_Receptor)
|
| gptkbp:bfsLayer |
6
|